Nikitin was knocked out of balance and crashed into the boards at full speed, causing him to put all of his weight on his left leg.
Zetterberg was assigned a five-minute major boarding penalty and a game misconduct, but will not face suspension.
Nikitin will miss the upcoming two contests and will be re-evaluated following the All-Star break. The injury is not expected to force him to miss significant time.
In 38 games with the Jackets this season, Nikitin has tallied two goals and 16 assists for 18 points.
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