The Sabres are scratching him from Tuesday night's game against the Detroit Red Wings.
Leino signed a six-year, $27 million contract with the Sabres on July 1, 2011 after picking up 19 goals and 53 points with the Philadelphia Flyers the season prior.
Leino has been riddled with injuries the last two seasons, having played in just eight games last season, but despite his ailments, the Sabres might have had enough of his poor production.
It has been widely speculated that the Sabres will buy out his contract this off-season.
This is the final year in the new CBA in which teams have the option of using up to two compliance buyouts. If used, those buyouts will not count against the salary cap.
The Sabres still have both of their compliance buyouts available to them.
Sabres GM Tim Murray is expected to make a number of moves this off-season, and buying out Leino may be one of them.