"He's going to miss some time," Sabres coach Lindy Ruff told the News. "It'll probably be weeks."
The Sabres traded for Ehrhoff over this summer and signed him to a 10-year, $40 million contract.
In 37 games with the Sabres this season, Ehrhoff has collected three goals and 14 assists for 17 points, and 28 penalty minutes.
The club has been hit hard by injuries since the start of the season as defenseman Tyler Myers and forwards Ville Leino, Corey Tropp, Tyler Ennis, Nathan Gerbe and Colin Stuart were all missing from the lineup on Friday.
The Sabres' 17-17-4 record and the potential long-term absence of Ehrhoff might push GM Darcy Regier to explore the trade market, looking to bolster their playoffs hopes.
Regier could use forward Derek Roy as trade bait as teams seeking a younger scoring center might consider him a suitable option. It was rumored that the Sabres tried to move him at the 2011 NHL Entry Draft, while he has faced criticism this season from fans and media over his subpar performance.
Roy has one-year left on his contract beyond this season at a cap hit of $4 million and could benefit from a change of scenery.